Thomas County agents say when they approached Joseph Poole and Stanley Haliburton they took off from the Pinecrest Apartments and headed south of US 19.
Agents say they chased the men almost to the Florida line where Poole, the driver, lost control of the car.
Kevin Lee of the Thomas County Drug Squad says, "The driver actually negotiated the curves pretty well. We were behind him at a safe distance and speed. He was in a straightaway and he swerved, we don't know why, and then he went off the road and hit the ditch and rolled several times."
Agents say the two men were taken to Archbold Hospital, and no injuries were reported
The men are facing several charges including possession of cocaine and aggravated assault on a peace officer.