Deputies say they plan to liquidate all cars, SUV's, lawnmowers and ATV's it's confiscated over the past decade.
Money made will be returned to the county and used to buy new equipment for drug agents.
Deputies say most of the vehicles came from drug trafficking.
"Most of 'em are seized vehicles and of course they're from all over the United States that's come through and we've stopped and seized drug paraphernalia out of the car," said Lowndes County Sheriff Chris Prine.
The auction will be held Saturday on the lawn of the Lowndes County Sheriff's Office at 10 a.m.