A Georgia State Patrol trooper on the scene says the accident occurred shortly after five o'clock Tuesday evening on Highway 84 near the town of Pitcock.
The trooper says the driver of the small car died after crossing the median and colliding with the tractor trailer.
Georgia State Patrol Senior Trooper Jeff Hunter says, "We had several witnesses that stated that the small vehicle hydro-planed, crossed the median over into the westbound lanes. The tractor-trailer traveling westbound t-boned the vehicle in the westbound lane."
The Georgia State Patrol isn't releasing the name or age of the deceased as of Wednesday evening.
Troopers say the driver of the tractor trailer was shaken up and is being treated at Brooks County Hospital.