It happened around 1:30 Thursday afternoon on I-10 in Madison County, Florida.
Florida troopers say a woman driving a silver dodge stratus was heading west when she lost control, crossed the median, and headed into the path of an oncoming tractor-trailer.
The two collided crushing the car and setting the truck on fire. Fire crews quickly put the fire out.
The woman was taken to Tallahassee Memorial in critical condition. The driver of the truck was also taken to the hospital in stable condition.
Troopers say wet roads and high speeds likely caused the accident.