London, ENG - Colin Kaepernick ran and threw his way to victory Sunday, leading the San Francisco 49ers over the Jacksonville Jaguars 42-10 at Wembley Stadium.
Kaepernick threw for 164 yards and one touchdown, and ran for 54 yards and two touchdowns. Frank Gore also ran for two scores.
The 49ers improved to 6-2 with the win, their fifth in a row, while the Jaguars remained winless at 0-8.
It was the eighth regular-season NFL game at Wembley, the home of England's national soccer team, and the second this year. The Minnesota Vikings beat the Pittsburgh Steelers 34-27 last month.