The crash happened on I-10 near mile marker 166 in Gadsden County just before 6 o'clock Saturday morning.
The florida highway patrol says 22-year-old Jessie William Conliffe of Quincy, Florida was driving west on I-10 when he veered from the inside lane into the outside lane hitting the rear of a truck causing it to rotate and overturn several times.
The driver of the truck 44 year-old Anwr Majaran of Margate, Florida was pronounced dead at the scene.
The passenger of the truck, Patricia Lucy Cortez, was taken to Tallahassee Memorial Hospital in critical condition.
Confliffe has been charged with DUI manslaughter and DUI with serious bodily injury.