Heated chemotherapy helping patients with signet ring cell carcinomas

Photo: NIH
Photo: NIH(WNDU)
Published: May. 22, 2019 at 1:51 PM EDT
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By: Ivanhoe Newswire

May 22, 2019

BALTIMORE, Md. (Ivanhoe Newswire) -- Signet ring cell carcinomas develop in the organs of the GI tract: the stomach, appendix, colon, bladder and pancreas. The cancer gets its name from the ring appearance the cells take on under the microscope.

It’s been historically tough to treat, but in select patients, surgery and a new method of delivering chemo have been making a difference.

Jim Gibbs, 67, was working full-time and feeling healthy until Superbowl Sunday 2016, when he had a sudden pain in his left side.

“The next day I was attending some meetings and it was there, nagging,” said Jim.

Jim’s wife, Carol Gibbs, said, “There were no signs. No other signs.”

A CT scan showed something unusual on his appendix. His doctor ordered more tests.

Jim shared, “He called me a week later and said, 'well, it’s cancerous and it’s signet ring cell cancer.'”

Surgical oncologist Vadim Gushchin, MD at Mercy Medical Center says signet ring cell carcinomas are aggressive. Patients have very few symptoms, so the cells often spread before they’re caught.

Dr. Gushchin explained, “By the time a typical diagnosis of a signet ring cell carcinoma of the stomach is made, the entire stomach is engulfed in tumor.”

Surgery may be a treatment option, but doctors can’t always remove all the cancer. For Jim, doctor Gushchin added HIPEC, heated intraoperative peritoneal chemotherapy.

Jim said, “They hook you up to a pumping system that pumps in heated chemotherapy and it bathes the entire abdominal cavity, and then they pump it out.”

Most cancers recur within two years after surgery, so Jim spent that time volunteering at cancer charity walks.

“I can look back and say, you know, I spent that time in the most life-giving way I could,” Jim said.

Jim finished his treatment more than two years ago, and he remains disease-free.

Doctor Gushchin cautions even with the addition of HIPEC, the cancer is still tough to wipe out. Gushchin says patients who do best with this treatment have no nodes involved, and have the tumor contained within one of the organs.